|Breast cancer is a malignant growth in the tissues of the breast. Each year more than 185,000 women are diagnosed with breast cancer, and the incidence of this disease is rising in developed countries. There are approximately 43,500 deaths from breast cancer annually, making this disease second to lung cancer as the leading cause of death by cancer among women.Note from me: Heart disease is the number one cause of death.While age, gender, family history, and hormone replacement therapy have been implicated as possible causes of breast cancer, recent clinical evidence indicates that various dietary factors may also play an influential role in its development. These factors may include omega-6 fatty acids.According to Dr. Hiroyuki Nakagawa and colleagues in the Journal of Cancer Research and Clinical Oncology, “The amount as well as type of fat appears to be an important determinant in that the essential n-6 polyunsaturated fatty acid, particularly linoleic acid,plays a key role in breast cancer stimulation.”In addition, researchers have hypothesized that resveratrol a bioflavonoid and phytoestrogen found mainly in grape skins, grape juice, red wine, mulberries, and peanuts may lessen the effects of a high-fat diet rich in linoleic acid. In order to further test its anticancer activity, researchers sought to determine the effects of resveratrol on breast cancer cell growth in a nutrient solution rich in linoleic acid.
After testing cell growth against varying doses of resveratrol, Dr. Nakagawa and colleagues claimed that “…pharmacological doses of resveratrol clearly diminished the ability of linoleic acid to stimulate growth of breast cancer cells.” Furthermore, researchers determined that the ability of resveratrol to “…suppress, retard, or reverse the process of carcinogenesis, is a promising strategy for the management of cancer.”
J Cancer Res Clin Oncol 2001;127:258-64.
Advanced Nutrition Publications ©2002